ZenoTOF 7600 System
Welcome to the Zeno revolution
Driven by the power of the Zeno trap coupled with electron-activated dissociation (EAD) fragmentation technology, this fragment-centric revolution unlocks sensitivity gains allowing you to uncover new information for certainty in your results to make better-informed decisions, faster.
Detect up to 20x more ions in every experiment and access a spectrum of tuneable fragmentation techniques to unlock new perspectives for every molecule in every experiment.
Harness the power of Zeno SWATH data-independent acquisition (DIA) to deliver a high depth of coverage, particularly on low abundance species, quickly and robustly. Routinely quantify up to twice the number of plasma proteins than previously possible and drive faster discovery of new disease markers and therapies.
The Zeno revolution is now...
Zeno trap, EAD, and Zeno SWATH DIA. A high-resolution mass spectrometry solution that combines MS/MS sensitivity, orthogonal fragmentation technology, and a step change in SWATH DIA.
- Characterize large molecules, including post-translational modifications
- Elucidate positional isomers on small molecules and lipids
- Identify and quantify proteins and peptides at unparalleled speed
- Gain significant sensitivity and discover less abundant ions
Overcome QTOF MS/MS duty cycle deficiencies
>90% ions injected into the TOF Sensitivity gains of up to 5-20X with Zeno trap pulsing Identify and quantify low-abundance species
Tuneable fragmentation of all molecule types
Utilize controlled electron-activated dissociation (EAD)
MS/MS Scan rates of up to 133 Hz
SWATH DIA, Improved DDA and MRMHR
Automation Enabled
- Optional 96-well plate sample loader module
- API (Application Programming Interface) allows external software to control the instrument
- For automated sample processing and data acquisition integrate with the Biomek i-Series Instrument
Zeno SWATH Data-Independent Acquisition (DIA)
Dive deeper into the biomarker landscape. Zeno SWATH DIA marks a significant step-change in data-independent acquisition delivering a high depth of coverage, particularly on low abundance species, quickly and robustly.
The Zeno trap in combination with SWATH Acquisition enables significant sensitivity gains through the use of Zeno trap enabling researchers to routinely quantify up to twice the number of plasma proteins than previously possible.
With sample loads as little as 10 ng and runtimes shortened to as little as 5 mins, large-scale biomarker studies can run as routine projects that are achieved in a matter of weeks, without compromising the depth of proteome coverage that can be obtained.
Zeno SWATH DIA allows the highest level of depth in your data in the shortest amount of time compared to traditional SWATH DIA.
A step-change in fragmentation technology
ELECTRON ACTIVATED DISSOCIATION (EAD)
EAD allows for a range of free electron based fragmentation mechanisms within one device. The ability to tune electron kinetic energy within an EAD experiment extends the utility of the approach to all molecules types, from singly charged small molecules to large multiply charged proteins.
Low EAD biomolecule analysis
Mid EAD post-translational modifications
High EAD small molecules
ZENO TRAP
The next era of sensitivity for accurate mass
Ions are accumulated in the Zeno trap before being pulsed rapidly into the TOF, meaning we can detect up to 20x more ions.
Consequently, each TOF experiment contains more useful MS/MS information, particularly on lower abundance species that were previously undetectable, introducing our customers to a new sensitivity revolution.
Without Zeno trap pulsing
With Zeno trap pulsing
Rare quantifiable data becomes your everyday
Zeno SWATH DIA
New depth of rare data.
Zeno EAD/ CID
Fresh perspective and certainty.
Zeno MRMHR
Fresh perspective and certainty.
Zeno enabled data landscape
Zeno SWATH DIA
Zeno DDA (CID/EAD)
Zeno MRM
Bringing integration, integrity and accessibility to large-scale data studies
SCIEX OS
SCIEX OS is built on a foundation of powerful algorithms and automation that enable efficient data interpretation, at scale, to the level needed for clinical relevance.
It's remarkable quantitative useability makes collaboration easy enabling researchers across labs, countries and continents to share insights and produce meaningful impact.
SCIEX OS is powering the Zeno revolution.
Flow rate
Turbo V source
- High sensitivity across 5 µL/min - 3 mL/min
- Compound class coverage
- APCI and ESI modes
Optiflow source
- Intelligent probe and electrode design
- Eliminates manual adjustment
- Minimized source optimization for the 1 -200 µL/min workflows.
Optiflow
Turbo V source
- Plug-and-play nanoflow capability
- Integrated column oven
- Nanoflow probe and electrodes